Huff | Trufflez Buds Truffle, also called Trufflez or Truffles, is an indica-dominant hybrid strain made by crossing Zkittlez x Cherry Noir. The effects of Truffle are believed to be relaxing. Reviewers on Leafly say this weed strain makes them feel sleepy, relaxed, and happy. The dominant terpene is caryophyllene, and Truffle has a tangy, coffee nose with sugary and ammonia notes.